HOCKE GROUP

Welcome to „Molecular Imaging of Immunoregulation“


Our group is part of the Department of Internal Medicine/Infectiology and Respiratory Diseases (Medizinische Klinik m.S. Infektiologie und Pneumologie) of the Charité – Universitätsmedizin Berlin.

Infections cause high rates of morbidity and mortality worldwide and among these pneumonia is the third most cause of death, especially for elderly and children under five years.

Since the introduction of antibiotics, the mortality rates for pneumonia remain rather constant and, with many other scientists, we make strong efforts to understand the underlying mechanisms of this severe disease.

Our mission is therefore to strengthen the understanding of such complex mechanisms to serve our aim for identifying new therapeutic immunomodulatory options for pneumonia and sepsis.

To contribute to this aim, we have established a 3D infection model based on human lung tissue on which we use and develop further functional life tissue microscopic applications to visualize the interaction between pathogens and the host from cellular down to molecular levels. These investigations are flanked by a broad spectrum of biochemical assays and molecular biological approaches on cell lines and primary human lung cells.

Please, create your own image of our work and don’t hesitate to apply on your own initiative!