PUBLICATIONS

Selected Publications:

 

  1. Röwekamp I*, Maschirow L*, Rabes A*, Fiocca Vernengo F, Hamann L, Heinz GA, Mashreghi MF, Caesar S, Milek M, Fagundes Fonseca AC, Wienhold SM, Nouailles G, Yao L, Mousavi S, Bruder D, Boehme JD, Puzianowska-Kuznicka M, Beule D, Witzenrath M; CAPNETZ Study Group; Löhning M, Klose CSN, Heimesaat MM, Diefenbach A, Opitz B. IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota. Proc Natl Acad Sci U S A. 2024 May 28;121(22):e2310864121.
  2. Dörner PJ, Anandakumar H, Röwekamp I, Fiocca Vernengo F, Millet Pascual-Leone B, Krzanowski M, Sellmaier J, Brüning U, Fritsche R, Pfannkuch L, Kurth F, Milek M, Igbokwe V, Löber U, Gutbier U, Holstein M, Heinz GA, Mashreghi MF, Schulte LN, Klatt AB, Caesar S, Wienhold SM, Offermanns S, Mack M, Witzenrath M, Jordan S, Beule D, Kirwan JA, Forslund SK, Wilck N, Bartolomaeus H, Heimesaat MM, Opitz B. Clinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lung. Nat Commun. 2024;15:2788.
  3. Klatt AB, Diersing C, Lippmann J, Mayer-Lambertz S, Stegmann F, Fischer S, Caesar S, Fiocca Vernengo F, Hönzke K, Hocke AC, Ruland J, Witzenrath M, Lepenies B, Opitz B. CLEC12A Binds to Legionella pneumophila but Has No Impact on the Host’s Antibacterial Response. Int J Mol Sci. 2023 Feb 15;24(4):3891.
  4. Thibeault C, Suttorp N, Opitz B. The Microbiota in Pneumonia: From Protection to Predisposition. Sci Transl Med. 2021;13(576):eaba0501
  5. Robak OH, Heimesaat MM, Kruglov AA, Prepens S, Ninnemann J, Gutbier B, Reppe K, Hochrein H, Suter M, Kirschning CJ, Marathe V, Buer J, Hornef MW, Schnare M, Schneider P, Witzenrath M, Bereswill S, Steinhoff U, Suttorp N, Sander LE, Chaput C*, Opitz B*. Antibiotic treatment-induced secondary IgA-deficiency enhances susceptibility to Pseudomonas aeruginosa J Clin Invest. 2018;128:3535-3545.
  6. Ruiz-Moreno JS, Hamann L, Shah JA, Verbon A, Mockenhaupt FP, Puzianowska-Kuznicka M, Naujoks J, Sander LE, Witzenrath M, Cambier JC, Suttorp N, Schumann RR, Jin L, Hawn TR, Opitz B; CAPNETZ Study Group. The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires‘ disease in humans. PLoS Pathog. 2018;14: e1006829.
  7. Naujoks N, Tabeling C, Dill BD, Hoffmann C, Brown AS, Kunze M, Kempa S, Peter A, Mollenkopf HJ, Dorhoi A, Kershaw O, Gruber AD, Sander LE, Witzenrath M, Herold S, Nehrlich A, Hocke AC, van Driel I, Suttorp N, Bedoui B, Hilbi H, Trost M, Opitz B. IFNs modify the proteome of Legionella-containing vacuoles and restrict infection via IRG1-derived itaconic acid. PLoS Pathogens. 2016;12:e1005408.
  8. Witzenrath M, Pache F, Lorenz D, Koppe U, Schönrock S, Meixenberger K, Dorhoi A, Ma J, Holmes A, Trendelenburg G, Heimesaat MM, Bereswill S, van der Linden M, Tschopp J, Mitchell TJ, Suttorp N, Opitz B. The NLRP3 Inflammasome is Differentially Activated by Pneumolysin Variants and Contributes to Host Defense in Pneumococcal Pneumonia. J Immunol. 2011;187:434-40.
  9. Opitz B, van Laak V, Eitel J, Suttorp N. Innate immune recognition in infectious and non-infectious diseases of the lung. Am J Respir Crit Care Med. 2010;181:1294-309.
  10. Eitel J, Krüll M, Hocke AC, N Guessan PD, Zahlten J, Schmeck B, Slevogt H, Hippenstiel S, Suttorp N, Opitz B. beta-PIX and Rac1 GTPase mediate trafficking and negative regulation of NOD2-dependent signalling. J Immunol. 2008;181:2664-71.
  11. Opitz B, Förster S, Hocke AC, Maass M, Schmeck B, Hippenstiel S, Suttorp N, Krüll M. Nod1 mediated endothelial cell activation by C. pneumoniae. Circ. Res. 2005;96:319-26.

Pubmed:

Bastian Opitz

Awards:

2022   Patrick Dörner, Poster Prize (3rd International Conference „Innate Immunity of the Lung“)
2019   Juan Sebastian Ruiz-Moreno, DGI-Promotionspreis
2019   Laura Maschirow, First Prize (DGHM/DGfI AKI – Arbeitskreis Infektionsimmunologie)
2018   Bastian Opitz, Wolfgang-Stille prize from the Paul-Ehrlich-Society
2017   Laura Maschirow, First Prize (DGHM/DGfI AKI – Arbeitskreis Infektionsimmunologie)
2016   Jan Naujoks, DGHM-Promotionspreis
2015   Jan Naujoks, First Prize (DGHM/DGfI AKI – Arbeitskreis Infektionsimmunologie)
2015   Jan Naujoks, Best Talk Award (SPP1580 Internal Meeting)
2014   Jan Naujoks, First Abstract Award (DGfI Annual Meeting)
2009   Bastian Opitz, Fritz-und-Ursula-Melchers-Preis (DGfI)